CD4/CD8 ratio trajectories and their impact on prognosis: a 15-year retrospective longitudinal cohort study of people living with HIV.

ABSTRACT:

Introduction

The aim of this study was to identify the heterogeneous classes of CD4/CD8 ratio trajectory and their impacts on prognosis in people living with HIV (PLHIV) during long-term antiretroviral therapy.

Methods

A retrospective cohort study of PLHIV receiving ART treatment was conducted in the Eighth Affiliated Hospital of Guangzhou Medical University, and the latent growth mixture model (LGMM) was used to identify the trajectories of longitudinal changes in the CD4/CD8 ratio between February 10, 2004, and January 31, 2019. Cox proportional hazard model and proportional subdistribution hazard model were conducted to explore the impact of CD4/CD8 ratio trajectory on prognosis.

Results

Three heterogeneous trajectories were identified: the baseline-low-level slow

SUBMITTER: Feng L 

PROVIDER: S-EPMC12357465 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature