<i>Chaetomium globosum</i> from <i>Alisma orientale</i> (Sam.) Juzep. enhances the antioxidative stress capacity of <i>Caenorhabditis elegans</i>.

ABSTRACT:

Background

Medicinal plant endophytic fungi hold significant potential for producing natural antioxidants, as they thrive in environments rich in bioactive antioxidant compounds.

Methods

This study focuses on Chaetomium globosum, an endophytic fungus isolated from Alisma orientale (Sam.) Juzep., to explore the in vivo antioxidant activity associated with the ethyl acetate extract (CGE) and to explore the underlying mechanisms.

Results

The results indicated that CGE treatment enhances the stress resistance in Caenorhabditis elegans, stimulates the antioxidant protection mechanisms of C. elegans, and exhibits strong antioxidant activity in vivo. RNA-seq analysis showed that CGE regulates Fatty acid degradation, glutathione metab

SUBMITTER: Shen N 

PROVIDER: S-EPMC12357546 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature