Association Between Urban Upbringing and Cortical Gyrification in Persons with Schizophrenia.

ABSTRACT:

Background

Many studies suggest that urban upbringing might increase the risk of developing schizophrenia (SCZ). However, the precise brain changes associated with urban upbringing remain poorly understood. In this study, we investigated how urban upbringing might influence cortical gyrification, a brain feature that reflects early structural development.

Methods

The study included 70 Healthy Controls (HC) and 87 individuals diagnosed with SCZ, all aged between 18 and 50 years. Participants and their caregivers were interviewed to collect information about birthplace and upbringing location. Based on data from the Indian Census (1971-2011), upbringing locations were categorized into three groups: rural, town, and city. An urbanicity index was calculated using a previously es

SUBMITTER: Korann V 

PROVIDER: S-EPMC12357842 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature