Dynamic brain-heart interaction in sleep characterized by variational phase-amplitude coupling framework.

ABSTRACT: Sleep is a complex physiological state characterized by synchronized cortical and cardiac oscillations, which reflect dynamic communication and interaction between the central (CNS) and autonomic (ANS) nervous systems, crucial for maintaining homeostasis and overall health. However, the dynamic interplay between CNS and ANS rhythmicities in sleep remains unclear. Here, we present a variational phase-amplitude coupling framework that associates frequency modulations of the electroencephalogram and cardiac R-peak intervals across sleep dynamics. We validate the robustness of our method on spurious couplings by nonlinear or nonstationary simulations. Moreover, delta-range slow cortical oscillations exhibit robust coupling with both the low- (HRV-LF) and high-frequency (HRV-HF) constituents of

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12357881 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature