Cardiorenal outcomes after herpes zoster reactivation in COVID-19 survivors from a global TriNetX study.

ABSTRACT: Herpes zoster (HZ) has emerged as a post-viral complication in COVID-19 survivors, but its long-term clinical impact remains uncertain. This retrospective cohort study utilized the TriNetX Global Collaborative Network to evaluate whether HZ reactivation after COVID-19 is associated with increased risks of mortality, cardiovascular, and renal outcomes. Adults diagnosed with HZ within one year of COVID-19 were propensity score-matched 1:1 with controls without HZ. A total of 48,442 matched patients were followed for three years. Compared with controls, HZ patients had significantly higher risks of major adverse cardiovascular events (HR: 1.38, 95% CI: 1.30-1.46), acute kidney injury (HR: 1.67, 95% CI: 1.55-1.80), and renal function decline defined by eGFR < 60 mL/min/1.73 m² (HR: 1.28, 95% C

SUBMITTER: Lu CL 

PROVIDER: S-EPMC12357886 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature