Synergistic effects of commensals and phage predation in suppressing colonization by pathogenic Vibrio parahaemolyticus.

ABSTRACT: Colonization resistance is a fundamental mechanism by which microbiomes suppress pathogen invasion; however, the ecological and mechanistic determinants of its efficacy remain incompletely understood. Here, we constructed a defined microbial consortium and employed in vivo shrimp infection models to investigate the synergistic interaction between commensal microbes and a pathogen-specific phage in suppressing the pathogen Vibrio parahaemolyticus. Our in vitro experiment revealed that combining key taxa, particularly with phage integration, markedly enhanced pathogen exclusion. Furthermore, we demonstrated that establishing the consortium prior to pathogen exposure resulted in the irreversible suppression of pathogen proliferation, highlighting the critical importance of timing. Mechanistic

SUBMITTER: Chen L 

PROVIDER: S-EPMC12357943 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature