Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory.

ABSTRACT: Brain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain. This paper investigates the foundational elements of learning and memory in neural organoids by quantifying immediate early gene expression in response to chemical modulation, input-specific short- and long-term synaptic plasticity, neuronal network dynamics, connectivity, and criticality to demonstrate the utility of these organoids in basic science research. Neural organoids showed synapse formation, glutamatergic and GABAergic receptor expression, immediate early gene expression basally and evoked, functional connectivity, criticality, and synaptic plasticity in response to theta-burst stimulation. In addi

SUBMITTER: Alam El Din DM 

PROVIDER: S-EPMC12357958 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature