MicroRNA profiles of four induced pluripotent stem cell lines derived from distinct tissues.

ABSTRACT:

Objective

Induced pluripotent stem cells (iPSCs) are generated from a vast number of adult cell types. While they all acquired embryonic stem cell (ESC)-like properties during reprogramming, differences in certain characteristics, including differentiation potential, remained. These differences are hypothesized to be due to epigenetic memory or individual genetic background.

Results

This study compared microRNA (miRNA) profiles, which is one aspect of epigenetic regulation, of four iPSC lines derived from dermal fibroblasts, hair follicle keratinocytes, peripheral blood T cells, and exfoliated renal epithelial cells by nCounter^® miRNA expression panels. 110 miRNAs were expressed in all iPSC lines, which accounted for 67.5-75.9% of expressed miRNAs in each line, wh

SUBMITTER: Trakarnsanga K 

PROVIDER: S-EPMC12358071 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature