Biomarker-based acute kidney injury sub-phenotypes refine risk assessment in children undergoing cardiac surgery.

ABSTRACT:

Background

Pediatric cardiac surgery-associated acute kidney injury (CS-AKI) is common with variable association with outcomes, possibly because transient serum creatinine (SCr) elevations are unrelated to kidney disease. Sub-phenotypes of CS-AKI with biomarker integration may provide prognostic enrichment. This study aims to determine if combining early postoperative urine neutrophil gelatinase-associated lipocalin (uNGAL) and SCr into sub-phenotypes strengthens associations with AKI and outcomes. We hypothesized that patients with early subclinical (uNGAL + , SCr -) or damage (uNGAL + , SCr +) CS-AKI would have more postoperative day 2-4 KDIGO-defined AKI and worse clinical outcomes than patients with early functional AKI (uNGAL - , SCr +).

Methods

Two-center prospective o

SUBMITTER: Pettit KA 

PROVIDER: S-EPMC12358096 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature