Increase of astrocyte apposition on GnRH neurons in early puberty onset induced by high fat diet.

ABSTRACT: Puberty onset is driven by the activation of GnRH-secreting neurons and can be advanced by obesity. Astrocytes are dynamic cells that react to changes in the central nervous system environment and participate in the regulation of energy balance and reproduction. To assess the interaction of GnRH neurons and hypothalamic astrocytes during the puberty transition in HFD-treated mice, female and male mice were divided into three groups according to the diet offered at weaning: 42% high-fat diet (HFD42%), 60% high-fat diet (HFD60%), or regular diet (CHOW). The effects of HFD on reproductive tissue and fat content during the prepubertal and pubertal transition were assessed. The impact of HFD on astrocyte interaction with GnRH neurons in the medial preoptic area (MPOA) and arcuate/median eminenc

SUBMITTER: Rodrigues-Santos I 

PROVIDER: S-EPMC12358207 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature