Design and Enzyme-Targeted Assessment of 1,2,4-Triazole-1,8-Naphthalimide Hybrids in Drug Discovery.

ABSTRACT: This study reports the design, synthesis, and biological evaluation of novel hybrid 1,2,4-triazole-1,8-naphthalimide derivatives using both classical and environmentally friendly synthetic routes. The synthetic strategy involved a multistep process starting with the preparation of triazolylthioacetic acid esters, followed by electrophilic cyclization-employing both conventional bromine and a green, bromine-free method-and culminating in amidation reactions to yield the target compounds. Structural modifications, including the incorporation of pyridinyl and benzoate moieties, were introduced to enhance biological activity. The compounds were evaluated for antimicrobial and anti-inflammatory activities. In antimicrobial assays, several derivatives demonstrated selective activity, with Compou

SUBMITTER: Korol N 

PROVIDER: S-EPMC12358230 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature