Identifying therapeutic targets for erectile dysfunction in the European population using genome-wide Mendelian randomization.

ABSTRACT:

Background

Erectile dysfunction (ED) is a prevalent condition with current treatments limited by suboptimal efficacy and adverse effects. Mendelian randomization (MR) offers a promising approach to identify potential genetic targets for novel therapies.

Aim

We performed a genome-wide MR study on druggable genes to find ED therapies.

Methods

We collected data on drug-targetable genes and their impact on blood expression quantitative trait loci (eQTLs). Using two-sample MR with genome-wide association studies data, we pinpointed genes linked to ED and conducted enrichment analysis. We also built protein networks and predicted drugs to support treatment development.

Outcomes

This comprehensive strategy provides a robust framework for the advancement of more effica

SUBMITTER: Guo P 

PROVIDER: S-EPMC12358251 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature