Integrating network pharmacology and transcriptomics to identify solasonine's anti-osteosarcoma targets and experimental validation.

ABSTRACT:

Background

Osteosarcoma (OS) patients face the challenge of having few effective therapeutic drugs. Solasonine(SS)is an active component of TCM against OS cells. This study aims to identify the key targets of solasonine in treating OS.

Methods

In this study, the transcriptome data and related gene sets were first downloaded from public databases. Subsequently, candidate targets were obtained by intersecting differentially expressed genes (DEGs) with solasonine and OS disease targets. Key targets were then identified through regression analyses, and a prognostic model was constructed. A nomogram was subsequently constructed using the key targets. The functions and immune microenvironment, as well as the structure, regulatory network, and molecular docking of these key targets

SUBMITTER: Wei D 

PROVIDER: S-EPMC12358266 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature