The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss.

ABSTRACT:

Introduction

Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown.

Methods

We compared abdominal and femoral subcutaneous adipose tissue (SAT) immune cell percentages between people with CO and AO before and after moderate (~10%) weight loss. We collected abdominal and femoral SAT from females with CO or AO before (CO: n=14; AO: n=13) and after (CO: n=8; AO: n=6) diet- and exercise-induced weight loss. We used flow cytometry to quantify the percentages of macrophages and

SUBMITTER: Murphy J 

PROVIDER: S-EPMC12358274 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature