Pirana and Integrated PMX Tools, a Workbench for NONMEM, NLME, pyDarwin, and RsNLME.

ABSTRACT: Keizer initially described Pirana as a workbench designed to streamline management of NONMEM modeling, visualization, and analysis. Initial versions of Pirana integrated tools included NONMEM and PSN. As new tools have become available to pharmacometricians, new capabilities have been added to Pirana. These capabilities include: Integration of the NLME engine via the R speaks NLME (RsNLME) package for developing NLME models Integration of a Shiny graphical interface for the construction of NLME models Integration of machine learning pyDarwin python package Integration of a Shiny interface for custom diagnostics including Goodness of Fit (GOF) plots, tables, Visual Predictive Check (VPC) and report shell generation Improved setup with support for parallel execution on a wide range of platfo

SUBMITTER: Chen R 

PROVIDER: S-EPMC12358299 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature