A Quantitative Systems Pharmacology Model That Describes Neurofilament Light Dynamics During Alzheimer's Disease Progression.

ABSTRACT: Neurofilament proteins are important constituents of neuronal cytoskeleton, along with microtubules. An increased concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and plasma is considered a potential biomarker of axonal degeneration, which occurs in various neurodegenerative diseases including Alzheimer's disease (AD). The goal of this study was to develop a QSP model describing the change in the concentration of NfL in the brain, CSF, and plasma during the progression of AD for populations of AD patients manifesting different combinations of biomarkers (amyloid, tau, brain atrophy), to estimate the contributions of different mechanisms to neurodegeneration. The model correctly describes the dynamics of neurofilament proteins during neurodegeneration processe

SUBMITTER: Maliukova P 

PROVIDER: S-EPMC12358314 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature