The C-type lectin receptor Dcir (<i>Clec4a2</i>) restrains <i>Aspergillus fumigatus</i> elimination by limiting the degranulatory activity of neutrophils.

ABSTRACT:

Introduction

C-type lectin receptors (CLRs) are innate sensors crucial for antifungal and antimycobacterial responses, contributing to host defenses against pathogens, including the ubiquitous mold Aspergillus fumigatus. Dendritic cell immunoreceptor (Dcir) modulates immune responses by limiting the development of inflammation and autoimmunity; however, its involvement in fungal infections has not been previously established.

Methods

Wild-type and Dcir-knockout C57BL/6J mice were infected with A. fumigatus intratracheally to establish a model of pulmonary aspergillosis. For in vitro analysis, neutrophils were purified from the bone marrow and incubated with A. fumigatus hyphae.

Results

Mice lacking Dcir exhibited improved clearance of A.

SUBMITTER: Yoshikawa FSY 

PROVIDER: S-EPMC12358354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature