Characterization of bronchus-associated lymphoid tissue induced by co-exposure to Asian sand dust and ovalbumin: a study using 3D serial section imaging.

ABSTRACT:

Introduction

Inducible bronchus-associated lymphoid tissue (iBALT) develops with different morphologies and functions depending on the type of antigen, in which various cytokines, such as interleukin (IL)-1 and IL-17, and the cells producing them, such as T helper 17 (Th17) and T follicular helper (T_fh) cells, play an important role. We recently observed that numerous inflammatory cells, mainly B cell like-cells forming peribronchial clusters, accumulate in the lungs of mice exposed to Asian sand dust (ASD), suggesting that ASD induced iBALT development. However, whether ASD induced iBALT formation, much less the mechanism by which ASD promotes iBALT formation, remains unknown.

Methods

B cell clusters were analyzed using the next generation serial section-three-di

SUBMITTER: Mikami Y 

PROVIDER: S-EPMC12358379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature