GABA receptor antagonism elicits feeding in the septohypothalamic nucleus.

ABSTRACT:

Introduction

Current rates of obesity and eating disorders have been steadily increasing, highlighting the importance of understanding the neural circuits of eating. This study explores the potential role of an understudied brain region, the septohypothalamic nucleus (SHy), in feeding control. Based on a serendipitous observation, we hypothesized that central injections of gamma-aminobutyric acid (GABA) receptor antagonists in the SHy would elicit feeding.

Method

Adult male Sprague-Dawley rats (n = 39) were microinjected with a vehicle or GABA_A receptor antagonists (bicuculline or picrotoxin) or a GABA_B receptor antagonist (2-(S)-(+)-2-hydroxy-saclofen [2-OH saclofen]). Food and water intakes were measured at 1, 2, 3, and 24 h after injection, an

SUBMITTER: Gabriella I 

PROVIDER: S-EPMC12358381 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature