Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke.

ABSTRACT:

Background

Thrombus burden considerably impacts ischemic stroke presentation and outcomes. However, the relationship between thrombus histology and volume has not been studied well. We investigated whether ischemic stroke thrombus composition and spatial distribution patterns differed with thrombus volume.

Methods

We enrolled patients with thrombi undergoing endovascular therapy (EVT) between July 2017 and July 2023. Thrombus volume on thin-section non-contrast computed tomography was measured using three-dimensional software. Immunohistochemistry analysis included fibrin, red blood cells (RBCs), and platelets. Thrombi were classified based on the overall distribution pattern of the components: layered, erythrocytic, mixed, and diffuse platelet. We analyzed the association b

SUBMITTER: Yun J 

PROVIDER: S-EPMC12358443 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature