Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.

ABSTRACT:

Introduction

Dopamine system dysfunction is closely associated with nervous system diseases such as Parkinson's disease and psychiatric disorder. Current research is limited to the individual application of dopamine D1 and D2 receptor-related agents, and the systematic effects of combined dopamine D1/D2 receptor inhibition on neural function remain unclear. In this study, we aimed to investigate the dose-dependent effects of co-DR1/2I (combined administration of dopamine receptor 1 inhibitor SCH39166 and dopamine receptor 2 inhibitor raclopride) on oxidative stress, learning, memory, emotion, and motor function in the substantia nigra, striatum, and hippocampus of mice.

Methods

After administering varying doses of co-DR1/2I through gastric tubes to male C57BL/6 mice, we used

SUBMITTER: Li X 

PROVIDER: S-EPMC12358472 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature