Inflammatory imbalance and activation deficits in T cells of myasthenia gravis patients revealed by proteomic profiling.

ABSTRACT: Myasthenia gravis (MG) is a heterogeneous autoimmune disorder characterized by neuromuscular transmission failure and skeletal muscle fatigability, with a pathophysiology involving both cellular and humoral immune components. Despite growing interest in the immunological etiology of MG, few functional studies have addressed the role of T cells, and most existing work has focused on quantifying immune cell subsets using flow cytometry. In this study, a comparative in vitro analysis of resting and activated CD4+ and CD8+ T cells from MG patients and healthy controls (HC) was performed using the multiplex Proximity Extension Assay (PEA) proteomics to assess the secretion of inflammatory proteins, including cytokines and chemokines, and to define the inflammatory status of T cells in MG

SUBMITTER: Bhandage AK 

PROVIDER: S-EPMC12358477 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature