Phthalate exposure is associated with subclinical coronary atherosclerosis: The Aragon Workers' Health Study (AWHS).

ABSTRACT:

Background and objectives

Phthalates are implicated in mechanisms underlying the development of cardiovascular disease, such as oxidative stress, lipid peroxidation, endothelial dysfunction, and activation of procoagulant pathways. This study aimed to evaluate the association between phthalate exposure and subclinical coronary atherosclerosis (SCA).

Methods

A total of 1119 Spanish male workers from a car assembly plant (mean age: 50.9 years) were included. Urinary metabolites of 11 phthalates and ΣDEHP were analyzed. SCA was defined as coronary artery calcium ≥ 100 Agatston units. Logistic regression models were used to estimate the association between phthalates (natural log-transformed) and SCA, adjusting for sociodemographic, lifestyle, and cardiovascular risk factors. Do

SUBMITTER: Merida DM 

PROVIDER: S-EPMC12358661 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature