Assessing Diversity Scaling in Lung Cancer Microbiome Across Individuals and Tissue Types.

ABSTRACT: The intra-tumor microbiome can impact the tumor's behavior by influencing its growth, inflammatory reactions, evasion of the immune system, genomic instability, and drug resistance. Altering this microbiota to improve the response to cancer treatment could offer fresh perspectives on cancer therapy. The very first step in intervening in the microbiome is to gain a deep understanding of how microbial diversity varies spatially and temporally between tissues or among individuals. Such changes can be investigated with the so-termed diversity-area relationship (DAR) modeling (Ma. 2018. Ecology and Evolution, 8(20), 10023-10038). This included examining the DAR profiles, Pairwise Diversity Overlap (PDO) profiles, Maximum Accumulated Diversity (MAD) profiles, and the ratio of local to global acc

SUBMITTER: Mei J 

PROVIDER: S-EPMC12358694 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature