Efficacy of Saffron (<i>Crocus sativus</i> L.) and Its Constituents on Breast Cancer, a Systematic Review of Preclinical Studies and Potential Therapeutic Mechanisms.

ABSTRACT:

Background

Breast cancer is the most common cancer and the main cause of death because of malignant tumors in women, worldwide. The impact of Crocus sativus on several cancers has been discussed. Recent studies provide evidence regarding the anticancer properties of C. sativus and its bioactive constituents against breast cancer. This study aims to systematically review the efficacy of this botanical drug and its constituents on breast cancer, and their mechanism of action for the first time. Due to the lack of human studies in this field, the present research focused on preclinical studies.

Methods

In this systematic review, scientific databases, including PubMed, Web of Sciences, Google Scholar, Scopus, and Scientific Information Database were explored profou

SUBMITTER: Hasheminasab FS 

PROVIDER: S-EPMC12358718 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature