First-Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors.

ABSTRACT:

Background

Co-occurrence of depression and diabetes is a prototypical example of mental-physical comorbidity. This study aims to investigate the association between first-degree family history of diabetes (FHD) and the presence of depressive symptoms.

Methods

The present work was one part of the baseline survey from the REACTION study. First-degree FHD was defined as having one or more first-degree relatives with diabetes. The Patient Health Questionnaire-9 was administered to detect the presence of depressive symptoms with its score ≥ 5. Logistic regression analyses were performed to determine the association between first-degree FHD and the presence of depressive symptoms.

Results

A total of 4804 participants were enrolled in the present study. Individuals with firs

SUBMITTER: Chen M 

PROVIDER: S-EPMC12358737 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature