Phytophthora Avr3a-Like Effectors Target and Inhibit Cinnamyl Alcohol Dehydrogenase CAD5 to Suppress Plant Immunity.

ABSTRACT: Phytophthora species are oomycetes that cause significant losses in agricultural production and damages to natural ecosystems. Phytophthora pathogens secrete numerous cytoplasmic effectors that target distinct cellular components to suppress host immunity and facilitate pathogen colonisation. The identification of their host targets is crucial for deciphering the mechanisms they employ to modulate host immunity. Here, we found that multiple Phytophthora Avr3a-like effectors interact with host plant cinnamyl alcohol dehydrogenase CAD5, as revealed by yeast two-hybrid and co-immunoprecipitation assays. Analysis of Arabidopsis thaliana T-DNA insertion mutants and overexpression lines, as well as analysis of RNA silencing Nicotiana benthamiana plants, showed that CAD5 positively regulates plan

SUBMITTER: Li L 

PROVIDER: S-EPMC12358741 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature