Association analysis-based screening strategy for quality markers of Tengdan capsule in the treatment of hypertensive renal disease.

ABSTRACT:

Background and aim

Hypertensive Renal Disease (HRD) is a chronic and progressive condition driven by sustained high blood pressure, which leads to renal fibrosis and, eventually, end-stage kidney failure. Tengdan Capsule (TDC), a traditional Chinese medicinal formulation, has shown therapeutic potential for managing HRD. However, the specific quality markers (Q-markers) responsible for its efficacy and the underlying molecular mechanisms remain insufficiently understood. This study aimed to identify candidate Q-markers of TDC and elucidate the molecular pathways through which it exerts its renoprotective effects, using an integrative association analysis-based approach.

Methods

The chemical composition of TDC and its potential Q-markers were systematically characterized thro

SUBMITTER: Liu J 

PROVIDER: S-EPMC12358744 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature