Dual function of <i>Desmidorchis retrospiciens</i>-derived gold nanoparticles as antibacterial and osteoinductive agent for treating osteomyelitis.

ABSTRACT:

Introduction

Osteomyelitis is a chronic inflammation of bone due to pathogenic infection mainly by methicillin-resistant Staphylococcus aureus (MRSA). Osteomyelitis can cause severe bone damage and pathologic fractures, which subsequently result in a high physical disability rate. Thus, a therapeutic agent with antibacterial and bone regenerative activities can be effective for managing osteomyelitis.

Methods

We phyto-fabricated gold nanoparticles using plant extract from Desmidorchis retrospiciens (DR-AuNPs) and examined their antibacterial and osteoinductive activities. The biosynthesis of DR-AuNPs was confirmed with several characterization techniques, including scanning and transmission electron microscopy, X-ray diffraction (XRD), energy-dispersive X-ray a

SUBMITTER: Abdallah BM 

PROVIDER: S-EPMC12358747 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature