Effects of hemodialysis on hemoglobin oxygen affinity and cardiac function.

ABSTRACT:

Background

Hemoglobin affinity for oxygen is modulated by ambient oxygen tension, acid/base status, 2,3 diphosphoglycerate (2,3DPG) concentrations and other factors, facilitating tissue oxygenation under changing conditions. 2,3DPG is a key regulator of oxygen affinity within red blood cells and its levels are affected by blood phosphate. P50, the partial pressure of oxygen at which 50% of its hemoglobin binding sites are occupied, is a marker of oxygen delivery to tissues. We measured P50 during hemodialysis and explored its relationship with mineral metabolites and left ventricular strain as a marker of cardiac function.

Methods

Venous blood gas and other laboratory parameters were measured in 20 prevalent patients pre- and post-hemodialysis. To avoid arterio-venous mixing

SUBMITTER: Sharma S 

PROVIDER: S-EPMC12358796 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature