New biomarkers of inflammation associated with haemodialysis.

ABSTRACT:

Background

The first year of haemodialysis (HD) carries the highest risk of mortality, which to a large extent is attributed to the aggravation of inflammation. However, traditional markers such as C-reactive protein and interleukin-6 show only minor changes during the first year, suggesting that there are other factors involved. The present study evaluates the effect of HD on microinflammation and oxidative stress of uremic patients.

Methods

We conducted a prospective observational longitudinal study including 30 incident HD patients. Blood samples were collected at baseline and 6 and 12 months. Pro-inflammatory monocytes were quantified using flow cytometry. Proteomic analysis (Olink) was performed on serum. Concentrations of indoxyl sulphate (IS), growth differentiation f

SUBMITTER: Guerrero F 

PROVIDER: S-EPMC12358798 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature