The timing of maternal protein degradation during mammalian preimplantation development is species-specific.

ABSTRACT:

In brief

Proper degradation of maternally inherited proteins is a prerequisite for successful embryonic development. This study shows the species-specificity of this process.

Abstract

The mechanism of targeting maternal proteins for degradation during preimplantation development is an unexplored process. Only a few proteins that need to be degraded for the proper course of the maternal-to-zygotic transition have been described in mice, and a few more in non-mammalian species. However, it is not well known whether the need for degradation is conserved across species or if it is driven in a species-specific way. Therefore, we selected six proteins that need to be degraded for the proper course of the maternal-to-zygotic transition in mice or Xenopus, and thoroughly characteriz

SUBMITTER: Kinterova V 

PROVIDER: S-EPMC12358800 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature