The Use of Medium-Deep Peelings to Treat Melasma: A Case Series Study.

ABSTRACT:

Objective

To evaluate the efficacy and safety of medium-deep chemical peels for melasma in a diverse population using quantitative and subjective methodologies for comprehensive outcome assessment.

Methods

A case series of 42 melasma region treatments was conducted from March 2023 to December 2024. Treatments included 30% phenol with 0.8% croton oil or a two-step protocol of 30% glycolic acid followed by 35% trichloroacetic acid (TCA) with 0.7% croton oil. Quantitative pigmentation analysis utilized the weighted skin intensity (WSI) ratio via Fiji ImageJ software. A panel of 20 experts conducted subjective evaluations based on standardized photographs, rating pigmentation reduction, skin tone uniformity, and overall appearance. Statistical analyses included the Wilcoxon sign

SUBMITTER: Scardua MT 

PROVIDER: S-EPMC12358819 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature