PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naive Prostate Cancer Patients.

ABSTRACT: PSA is the most common biomarker used in the screening and monitoring of prostate cancer. However, changes in PSA do not always reflect disease dynamics in every patient, and antihormonal agents may modulate its levels without significant antitumor effects. Changes in circulating tumor cells (CTC) have been described as a more objective measure of treatment response. Differences between PSA and CTC may be explained by heterogeneity in tumor cells producing PSA. To explore this, we measured the PSA secretion from a single CTC to gain insights into the PSA secretion heterogeneity between tumor cells. CTCs were enriched using EpCAM-based immunomagnetic enrichment in diagnostic leukapheresis of 18 patients with metastatic castration-naïve prostate cancer (mCNPC) not pretreated with any therapy

SUBMITTER: Dathathri E 

PROVIDER: S-EPMC12358827 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature