Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates.

ABSTRACT: During development, groups of cells generate shape by coordinating their mechanical properties through an interplay of self-organization and prepatterning. Hydra displays a striking planar pattern of actin fibers at the organism scale, and mechanics influence the morphogenesis of biological structures during its prepatterned regeneration. However, how mechanics participate in the formation of an ordered pattern from a totally disordered state remains unknown. To study this, we used cellular aggregates formed from dissociated Hydra cells, which initially lose all actin polarity yet regenerate a long-range actin pattern. We showed quantitatively that the actin meshwork evolves from a disordered symmetric state to an ordered state in which rotational symmetry is broken, and translation symmet

SUBMITTER: Bailles A 

PROVIDER: S-EPMC12358849 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature