Joint effects of elevated homocysteine levels and low eGFR on post-stroke cognitive impairment.

ABSTRACT:

Introduction

The correlation between serum homocysteine levels and post-stroke cognitive impairment (PSCI) remains inconsistent. This study aimed to investigate whether serum homocysteine levels are independently associated with PSCI and to assess the effects of renal function on this relationship.

Methods

A retrospective analysis was conducted in 608 patients with ischemic stroke. Homocysteine levels were obtained from inpatient medical records, and global cognitive function status 1 month after discharge was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The relationship between homocysteine levels and PSCI was evaluated using univariate and multiple linear and logistic regression analyses.

Results

The mean age

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12358956 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature