A brain-derived tau oligomer polymorph is associated with cognitive resilience to Alzheimer's disease.

ABSTRACT:

Introduction

Misfolded tau can assemble into oligomers that adopt distinct conformations, referred to as polymorphs, each with unique biochemical and pathological properties. These tau polymorphs are thought to influence disease progression in Alzheimer's disease (AD) and related disorders. Interestingly, some individuals with AD pathology remain cognitively intact (non-demented with Alzheimer's neuropathology [NDAN]), suggesting potential differences in tau polymorph profiles.

Methods

Brain-derived tau oligomers (BDTOs) were isolated from post mortem hippocampi of AD and NDAN individuals. Their biophysical, biochemical, and functional properties were assessed via protease digestion, immunocharacterization, atomic force microscopy, tau seeding in biosensor cells, hippocampal

SUBMITTER: Marcatti M 

PROVIDER: S-EPMC12359067 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature