Oral Disease and Atherosclerosis May Be Associated with Overlapping Metabolic Pathways.

ABSTRACT:

Objectives

Dental caries and periodontitis are among the most prevalent chronic diseases worldwide and have been associated with atherosclerotic cardiovascular diseases (ASCVD). This study aimed to determine (1) the independent associations between subclinical ASCVD markers (carotid intima media thickness [CIMT] and coronary artery calcification [CAC]) and quantitative indices of oral disease including the decayed, missing, and filled teeth (DMFT) index, gingivitis parameters, periodontal status, and number of teeth lost and (2) the extent to which metabolites altered in individuals with oral disease overlapped with those altered in individuals with ASCVD.

Methods

We used data from 552 participants recruited through the Dental Strategies Concentrating on Risk Evaluation proj

SUBMITTER: Bezamat M 

PROVIDER: S-EPMC12359100 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature