In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis.

ABSTRACT: Collagen membranes are widely used in tissue and bone engineering, including guided bone regeneration (GBR). For effective and uninterrupted bone healing, a GBR membrane must maintain its functionality for an initial critical period of 4 weeks. A novel carp collagen sponge has already shown promise as a wound coating and vascular graft coating, making it a candidate for GBR applications as well. To enhance the mechanical properties and longevity of GBR membranes, we modified the basic carp collagen membrane with combinations of l-lactide, ε-caprolactone, d,l-lactide, and glycolide in various molar ratios. While traditional methods rely on histological evaluation to assess the degradation pattern and therefore suitability of GBR membranes ex vivo, this study employed micro-MRI as an innovat

SUBMITTER: Bujda M 

PROVIDER: S-EPMC12359101 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature