Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review.

ABSTRACT: Clozapine is superior in the treatment of treatment-refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose-dependent side effects. This systematic review evaluates saliva as a more patient-friendly sampling strategy for clozapine TDM. A systematic search was carried out using MEDLINE, Embase, APA PsycInfo, and Cochrane Central Register of Controlled Trials (CCTR) through Ovid. Studies were eligible for inclusion if data on clozapine pharmacokinetics in saliva were described. To assess the feasibility of saliva for the TDM of clozapine, ease of saliva collection, method of detection, detectability of clozapine in saliva, correlation of clozapine concentrations in saliva compared to blood, clozapine stability in saliva, and

SUBMITTER: Rademaker T 

PROVIDER: S-EPMC12359200 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature