PTH stimulation of Rankl transcription is regulated by SIK2 and 3 and mediated by CRTC2 and 3 through action of protein phosphatases 1, 2, 4, and 5.

ABSTRACT: Osteoporosis is characterized by a decrease in the density and quality of bone tissue and is associated with substantial morbidity/mortality. Homeostatic processes that form new and remove old/damaged bone are dysregulated, with resultant net bone resorption. Parathyroid hormone (PTH) is a key regulator of this homeostasis and along with its analogs has been used to treat osteoporosis, however its use is limited to an "anabolic window". PTH stimulates both formation and resorption, the latter largely due to increased receptor activator of nuclear factor kappa-β ligand (RANKL). Our laboratory has found a cascade of messengers, Salt-inducible kinases (SIKs) and protein phosphatases (PPs), regulate nuclear translocation of CREB-regulated transcriptional coactivators (CRTCs), but the individua

SUBMITTER: Mosca MJ 

PROVIDER: S-EPMC12359225 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature