Uncovering the role of the Hsp40 family member cysteine string protein-α in mouse platelets.

ABSTRACT:

Abstract

Platelets modulate vascular microenvironments via the release of cargo molecules. Granule secretion is modulated by proteins called soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs). Secretion is complex and regulated by several protein-protein interactions; however, not all are characterized in platelets. We have identified cysteine string protein-α (CSPα; also known as, DNAJC5 or CLN4) as required for platelet secretion. CSPα is the only member from the CSP family present in platelets and has been proposed as a chaperone for the SNAP-23/25 t (Qb,c) SNAREs. To address CSPα's role, we analyzed platelets from CSPα-/- mice. The loss of CSPα significantly affected dense- and α-granule release with minimal effects on lysosomal secretion. Consisten

SUBMITTER: Smith AN 

PROVIDER: S-EPMC12359227 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature