Clinical and economic research of bone modifiers as adjuvant therapy for early breast cancer: A systematic literature review.

ABSTRACT:

Background

Adjuvant bisphosphonate therapy is recommended by some guidelines for postmenopausal breast cancer, but its application is not ideal due to inconsistent study results and economic burden considerations. This review aims to provide a comprehensive overview of bone modifiers in breast cancer adjuvant treatment to inform clinical practice and health policy.

Methods

PubMed, Embase, Cochrane Library, and Web of Science were searched using terms related to bone modifiers and breast cancer. The included studies comprised clinical trials evaluating adjuvant bone modifiers in early breast cancer (EBC) that reported recurrence, metastasis, or survival outcomes, as well as economic studies that reported costs and effects. Quality was assessed using Cochrane Risk of Bias tool

SUBMITTER: Wu W 

PROVIDER: S-EPMC12359659 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature