Cross-Sectional Analysis of Metabolic Tumor Burden Detected by F-18 FDG PET/CT and Circulating Tumor DNA in Advanced Breast Cancer.

ABSTRACT:

Background

This study investigated the relationship between circulating tumor DNA (ctDNA) parameters and metabolic parameters from FDG PET/CT in advanced breast cancer (ABC) patients.

Methods

In this retrospective single-center study, 47 ABC patients who underwent both liquid biopsy and FDG PET/CT were analyzed.

Results

Results showed that 27 patients (57.4%) had detectable ctDNA. Patients with detectable ctDNA demonstrated significantly higher whole-body metabolic tumor volume (WB-MTV) (p = 0.002) and whole-body total lesion glycolysis (WB-TLG) (p = 0.006) compared to those without ctDNA, while no significant difference was found in SUVmax or SUVmean. A moderate correlation was observed between variant allele frequency (VAF) values and metabolic parameters: maximum V

SUBMITTER: Tokac RH 

PROVIDER: S-EPMC12359722 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature