Identification of neoantigen epitopes in cervical cancer by multi-omics analysis.

ABSTRACT:

Background

Tumor vaccines enhance the immune response and cytotoxicity of tumor-specific T cells and show promising clinical therapeutic efficacy. Although most cervical cancer cells express HPV-related oncoproteins, some do not. Additionally, neoantigens worth attracting attention for cervical cancer (CC) may hold the potential for breakthroughs in the development of cervical cancer vaccines.

Methods

A comprehensive computational analysis was conducted based on the tumor genome, transcriptome, and proteome data from 284 cervical cancer samples obtained from the TCGA database. Frequently mutated genes were identified. The levels of immune cell infiltration were analyzed using RNA-seq data, high-frequency mutated genes were identified as candidate genes that were significantl

SUBMITTER: Yuan J 

PROVIDER: S-EPMC12359836 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature