Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses.

ABSTRACT:

Introduction

In Brazil, three COVID-19 vaccines were among the first widely used (CoronaVac, ChAdOx1, and BNT162b2), which aimed to induce neutralizing antibodies (NAbs) against the original SARS-CoV-2 strain. Although effective against severe disease, they showed waning NAb levels and reduced efficacy against variants, prompting booster doses. Thus, it is important to investigate and compare the response induced by these vaccines and boosters.

Methods

In this study, we compare the magnitude, durability, and cross-reactivity of NAbs among vaccinated volunteers in Brazil using an enzyme-linked immunosorbent assay (ELISA)-based assay that measures Abs capable of blocking the interaction between the receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2)

SUBMITTER: Caetano BLL 

PROVIDER: S-EPMC12359843 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature