Dataset Information
TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target.
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ABSTRACT:
SUBMITTER: Zheng Z
PROVIDER: S-EPMC12359846 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
Publications
TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target.
BMC cancer 20250818 1
The T-LAK cell-originated protein kinase (TOPK) has been associated with poor prognosis in various cancers, yet its specific role in kidney renal clear cell carcinoma (KIRC) remains unclear. In this study, we conducted a comprehensive investigation of TOPK expression and its association with immune infiltration in KIRC by integrating bioinformatics, in vitro, and in vivo approaches. We found that TOPK is significantly overexpressed in KIRC and serves as an independent prognostic marker correlate ...[more]