Optimal gestational weight gain in women with pregestational type 2 diabetes: a population-based cohort study in China.

ABSTRACT:

Background

The global prevalence of pregestational type 2 diabetes mellitus (T2DM) has increased concurrently with increasing rates of overweight and obesity. Effective weight management during pregnancy is critically associated with maternal and neonatal outcomes. However, no universally accepted guidelines for gestational weight gain (GWG) in high-risk pregnancies with T2DM currently exist.

Methods

A nationwide, multicenter cohort of 2078 T2DM pregnancies was analyzed, categorizing GWG based on latest Chinese guidelines. Multivariate regression analyses were performed to evaluate the impact of GWG deviations on adverse pregnancy outcomes. Interquartile range (IQR) analysis and restricted cubic splines were used to determine BMI-specific GWG targets.

Results

The resu

SUBMITTER: Xue Y 

PROVIDER: S-EPMC12359865 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature