Inhibition of c-Abl suppresses the proliferation, invasion and migration of glioma cells.

ABSTRACT:

Background

The proto-oncogene c-Abl has been implicated in tumor progression across multiple cancer types, but its role in glioma remains poorly understood. This study aimed to investigate the function of c-Abl in glioma progression and assess its potential as a therapeutic target.

Methods

High-throughput RNA sequencing was conducted on U-87 glioma cells following c-Abl knockdown. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to explore the biological pathways involved. Functional assays, including MTS for cell viability, Transwell assays for invasion and migration, and immunofluorescence (IF), were performed to evaluate cellular behavior in vitro. In vivo, a mouse xenograft model was treated with the c-Abl inhibitor dasa

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12359917 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature