Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways.

ABSTRACT:

Background

Oxidative stress can impair intestinal barrier function and cause liver damage, resulting in reduced animal productivity. Paraquat (PQ) induces significant oxidative stress in weaned piglets. The antioxidant, anti-inflammatory, and metabolic regulatory functions of taurine (Tau), a free amino acid that is widely distributed in the body, have been extensively studied. However, the mechanisms by which dietary Tau alleviates oxidative stress and gut-liver axis damage in weaned piglets remain unclear.

Methods

Forty weaned piglets (20 males and 20 females; 6.41 ± 0.11 kg; 25 days old; Duroc × Landrace × Yorkshire) were used in a 2 × 2 factorial design to investigate the mechanism by which dietary Tau (0% or 0.4%) alleviates PQ-induced oxidative stress and gut-liver axi

SUBMITTER: Chen C 

PROVIDER: S-EPMC12359926 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature